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GC-MS analysis indicated the major metabolic processes to be sequential reduction of the A-ring and hydroxylation at C6 and C16. After oral administration of nerobol, only small amount of its metabolites could be detected in urine of control or patients with hepatic diseases. A significant increase in TBK occurred in the treated group, primarily in the first 6 mo; thereafter the TBK remained fairly constant. A two compartment, double-blind, randomized, parallel study was performed comparing methandrostenolone with placebo in the treatment of osteoporosis. Resistance to the effects of neuromuscular blockers may occur.
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The MAO-A activity was increased in the oxymetholone-treated rats while the other treatment groups were unaffected. The DOPAC+HVA/DA ratio was increased in the striatum in all treatment groups. The androgens affected cardiac protein balance by stimulating the incorporation of radiolabelled amino acid into protein in vivo. Concentrations of testosterone receptors in ventricular cytosol further indicated that the myocardium is more sensitive to androgen action during the prepubertal phase of the life-span. Protein synthesis was inhibited in the castrate rat and was stimulated by subsequent treatment with androgen.
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